The Ministry of Health is the national coordinator for Italy within NANoREG project and it plays also a coordinating role on all the national structures involved in the management of risks of chemicals, including nanomaterials. 

Istituto Superiore di Sanità (ISS) contributes in translating policy issues into regulatory questions and scientific data gaps also fostering the dialogue between regulators and stakeholders. ISS is involved in vivo repeated-dose oral toxicity studies in rat and in several in vitro studies on: intestinal permeability, absorption and repeated exposure to nanoparticles with Caco-2 cell model, genotoxicity and pro-inflammatory response evaluation on human bronchial epithelial cells, in collaboration with Istituto Nazionale per l’Assicurazione contro gli Infortuni sul Lavoro (INAIL), on inflammatory properties, immunological functions and immunotoxicity in mouse primary cells and lines. ISS also interacts with international organizations and national NANoREG coordinators and contributes to dissemination and communication activities.
www.iss.it

Agenzia nazionale per le nuove tecnologie, l’energia e lo sviluppo economico sostenibile (ENEA) is contributing in regulatory oriented activities such as NM identification and analyis along the value chain, identification of exposure determinants, use descriptors and exposure scenarios. Development and implementation of an LCA methodology for NMs and development of tools for “nano” ecodesign in the innovation process and support the decision making process are other ENEA’s activities within the project. ENEA is also studying systemic genotoxic effects of NM in blood of rodents and addressing phys-chem characterization of NMs in relevant environmental matrices while assessing the ecotoxicological impact of NM in aquatic and terrestrial ecosystem.
www.enea.it/it

Istituto Italiano di Tecnologia (IIT) brings its expertise on the synthesis of NPs with accurate control of chemical-physical properties, in-situ characterization of NMs, analysis of nano-bio interactions, protein corona effects,  stability/agglomeration of NMs in biological fluids, effects on NMs size and surface charge, effective delivered dosages, cellular uptake. Biokinetics and Toxicity testing in vivo studies are also performed in collaboration with University of Rome Tor Vergata).
www.iit.it
http://web.uniroma2.it

Consiglio Nazionale delle Ricerche (CNR) is involved in chemical manufacturing processes aiming at innovative functionalities in molecular, macromolecular and complex solid systems with a different level of structural organization. CNR collaborates with Università di Torino, on the field of nanotoxicity and biocompatibility for the study of the safety of new materials. CNR is also collaborating with the other partners involved in dissemination activities.
www.cnr.it
www.centroscansetti.unito.it

Veneto Nanotech (VN) contributes to industrial technology transfer into the identification and the refinement of new upcoming regulatory issues. VN participates to characterization of NM through the different stages of their life cycle. VN will participate actively to the discussion on testing strategies and research priorities thanks to its experience in EU projects and industrial relationships. VN is also participating to dissemination activities.
www.venetonanotech.it/it